Design, Synthesis, Molecular Docking, and Anticancer Activity of Phthalazine Derivatives as VEGFR-2 Inhibitors-Reference-Cited by-同舟云学术

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Design, Synthesis, Molecular Docking, and Anticancer Activity of Phthalazine Derivatives as VEGFR-2 Inhibitors

Published:2017-11-13 Issue:12 Volume:350 Page:1700240
ISSN:0365-6233
Container-title:Archiv der Pharmazie
language:en
Short-container-title:Arch. Pharm. Chem. Life Sci.

Author:

El-Helby Abdel-Ghany A.¹,Ayyad Rezk R. A.¹²,Sakr Helmy¹,El-Adl Khaled¹^ORCID,Ali Mamdouh M.³,Khedr Fathalla¹

Affiliation:

1. Pharmaceutical Chemistry Department; Faculty of Pharmacy; Al-Azhar University; Cairo Egypt

2. Pharmaceutical Chemistry Department; Faculty of Pharmacy; Delta University; Gamasa Dakahlia Egypt

3. Biochemistry Department; Division of Genetic Engineering and Biotechnology; National Research Centre Dokki Giza Egypt

Publisher

Wiley

Subject

Drug Discovery,Pharmaceutical Science

Reference37 articles.

1. Vascular Endothelial Growth Factor as an Anti-Angiogenic Target for Cancer Therapy

2. Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition

3. Vascular endothelial growth factors and receptors: Anti-angiogenic therapy in the treatment of cancer

4. Design, synthesis and in vitro antitumor activity of novel N-substituted-4-phenyl/benzylphthalazin-1-ones

5. Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives

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3. A Microwave‐Assisted One‐Pot Three‐Step Metal‐Free [4+2] Annulation for the Sustainable Synthesis of Highly Substituted 1,2,4‐Triazines;European Journal of Organic Chemistry;2024-05-13

4. Iodoquinazoline-derived VEGFR-2 and EGFRT790M dual inhibitors: Design, synthesis, molecular docking and anticancer evaluations;Bioorganic Chemistry;2024-02

5. 2‐Thioxo‐3,4‐dihydropyrimidine and thiourea endowed with sulfonamide moieties as dual EGFR^T790M and VEGFR‐2 inhibitors: Design, synthesis, docking, and anticancer evaluations;Drug Development Research;2024-01-27

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