N-(2-(Piperazin-1-yl)phenyl)arylamide Derivatives as β-Secretase (BACE1) Inhibitors: Simple Synthesis by Ugi Four-Component Reaction and Biological Evaluation-Reference-Cited by-同舟云学术

N-(2-(Piperazin-1-yl)phenyl)arylamide Derivatives as β-Secretase (BACE1) Inhibitors: Simple Synthesis by Ugi Four-Component Reaction and Biological Evaluation

Published:2015-03-19 Issue:5 Volume:348 Page:330-337
ISSN:0365-6233
Container-title:Archiv der Pharmazie
language:en
Short-container-title:Arch. Pharm. Chem. Life Sci.

Author:

Edraki Najmeh¹,Firuzi Omidreza¹,Fatahi Yousef²,Mahdavi Mohammad²,Asadi Mehdi²,Emami Saeed³,Divsalar Kouros⁴,Miri Ramin¹,Iraji Aida¹,Khoshneviszadeh Mehdi¹,Firoozpour Loghman⁵,Shafiee Abbas²,Foroumadi Alireza²⁴

Affiliation:

1. Medicinal and Natural Products Chemistry Research Center; Shiraz University of Medical Sciences; Shiraz Iran

2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center; Tehran University of Medical Sciences; Tehran Iran

3. Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy; Mazandaran University of Medical Sciences; Sari Iran

4. Neuroscience Research Center, Institute of Neuropharmacology; Kerman University of Medicinal Sciences; Kerman Iran

5. Drug Design and Development Research Center; Tehran University of Medical Sciences; Tehran Iran

Publisher

Wiley

Subject

Drug Discovery,Pharmaceutical Science

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/ardp.201400322/fullpdf

Reference19 articles.

1. A? Oligomers ? a decade of discovery

2. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

3. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics