Predictors of autism spectrum disorder diagnosis in a spanish sample of preterm children with very low birthweight: A cross‐sectional study

Author:

Magán‐Maganto María1ORCID,Canal‐Bedia Ricardo1ORCID,Bejarano‐Martín Álvaro1ORCID,Martín‐Cilleros Maria Victoria1ORCID,Hernández‐Fabián Aránzazu2,Calvarro‐Castañeda Andrea Luz1,Roeyers Herbert3ORCID,Jenaro‐Río Cristina4ORCID,Posada de la Paz Manuel5ORCID

Affiliation:

1. University Institute of Community Integration (INICO), Centro de Atención Integral al Autismo (INFOAUTISMO), Faculty of Education Universidad de Salamanca Salamanca Spain

2. Pediatrics, Hospital Universitario de Salamanca Universidad de Salamanca Salamanca Spain

3. Department of Experimental Clinical and Health Psychology, Research in Developmental Disorders Lab (RIDDL) Ghent University Ghent Belgium

4. University Institute of Community Integration (INICO), Faculty of Psychology Universidad de Salamanca Salamanca Spain

5. Rare Diseases Institute of Rare Diseases Research & Institute of Health Carlos III Madrid Spain

Abstract

AbstractBackground and AimsAutism spectrum disorder (ASD) is a neurodevelopmental disorder with a higher likelihood of being diagnosed in preterm populations. Likewise, low birthweight has also been connected with an increased likelihood of ASD. The objectives were to study the frequency and define the relationship between ASD, gestational age, birthweight, and growth percentiles for preterm children.MethodsA sample of preterm children with very low birthweight was selected from the Spanish population at 7–10 years old. Families were contacted from the hospital, and they were offered an appointment to conduct a neuropsychological assessment. The children who showed signs of ASD were referred to the diagnostic unit for differential diagnosis.ResultsA total of 57 children completed full assessments, with 4 confirmed ASD diagnoses. The estimated prevalence was 7.02%. There were statistically significant weak correlations between ASD and gestational age (τb = −0.23), and birthweight (τb = −0.25), suggesting there is a higher likelihood of developing ASD for those born smaller or earlier in their gestation.ConclusionThese results could improve ASD detection and outcomes for this vulnerable population while also supporting and enhancing previous findings.

Funder

Ministerio de Economía y Competitividad

Ministerio de Ciencia e Innovación

Junta de Castilla y León

Publisher

Wiley

Subject

General Medicine

Reference32 articles.

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3. Instituto Nacional de Estadística Estadística de nacimientos. Datos definitivos. Resultados detallados. Año. 2020. Accessed June 29 2022.https://www.ine.es

4. Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies)

5. Academic performance of children born preterm: a meta-analysis and meta-regression

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