A highly sensitive LC-tandem MS assay for the measurement in plasma and in urine of salbutamol administered by nebulization during mechanical ventilation in healthy volunteers

Author:

Sidler-Moix Anne-Laure1,Mercier Thomas2,Decosterd Laurent A.2,Di Paolo Ermindo R.1,Berger-Gryllaki Markoulina1,Cotting Jacques3,Pannatier André1

Affiliation:

1. Department of Pharmacy; University Hospital; Lausanne; Switzerland

2. Division of Clinical Pharmacology and Toxicology; University Hospital; Lausanne; Switzerland

3. Pediatric Intensive Care Unit; University Hospital; Lausanne; Switzerland

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference26 articles.

1. Treatment of bronchopulmonary dysplasia;Barrington;Clinics in Perinatology,1998

2. Determination of salbutamol and detection of other beta-agonists in human postmortem whole blood and urine by GC-MS-SIM;Black;Journal of Analytical Toxicology,1999

3. Determination of albuterol concentrations in human plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection;Bland;Journal of Pharmaceutical and Biomedical Analysis,1990

4. The pharmacokinetics of levosalbutamol: what are the clinical implications?;Boulton;Clinical Pharmacokinetics,2001

5. Physicochemical aspects of nebulization: comparison of five models of jet nebulizers;Di Paolo;European Journal of Hospital Pharmacy Science,2000

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