Glyceraldehyde 3-phosphate dehydrogenase modulates nonoxidative pentose phosphate pathway to provide anabolic precursors in hypoxic tumor cells

Author:

Ahn Woo S.1,Dong Wentao1ORCID,Zhang Zhe1,Cantor Jason R.2345,Sabatini David M.2345,Iliopoulos Othon678,Stephanopoulos Gregory1

Affiliation:

1. Dept. of Chemical Engineering; Massachusetts Institute of Technology; Cambridge MA 02139

2. Dept. of Biology; Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology; Cambridge MA 02142

3. Dept. of Biology; Howard Hughes Medical Institute, Massachusetts Institute of Technology; Cambridge MA 02139

4. Koch Institute for Integrative Cancer Research; Cambridge MA 02139

5. Broad Institute of Harvard and Massachusetts Institute of Technology; Cambridge MA 02142

6. Center for Cancer Research; Massachusetts General Hospital Cancer Center; Boston MA 02114

7. Dept. of Medicine; Harvard Medical School; Boston MA 02115

8. Division of Hematology-Oncology, Dept. of Medicine; Massachusetts General Hospital; Boston MA 02114

Funder

National Institutes of Health

Publisher

Wiley

Subject

General Chemical Engineering,Environmental Engineering,Biotechnology

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