Changes to culture pH and dissolved oxygen can enhance chimeric antigen receptor T‐cell generation and differentiation
Author:
Affiliation:
1. Cell Culture and Fermentation Sciences MedImmune LLC, One MedImmune Way Gaithersburg Maryland USA
Publisher
Wiley
Subject
Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.3275
Reference11 articles.
1. Manufacturing a hurdle Novartis has yet to clear;Pagliarulo N;Biopharma Dive,2018
2. Towards a commercial process for the manufacture of genetically modified T cells for therapy
3. Extracellular pH Affects the Proliferation of Cultured Human T Cells and Their Expression of the Interleukin-2 Receptor
4. Effects of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes
5. Demonstrating the Manufacture of Human CAR‐T Cells in an Automated Stirred‐Tank Bioreactor
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