Serum oxidative biomarkers associated with genital HPV infection and cervical lesions in women

Author:

Lin Hui‐Yi1ORCID,Zhu Xiaodan1,Mazumder Harun Or Rashid1,Ronis Martin2,Pedersen Kim Brint2,Hagensee Michael3

Affiliation:

1. Biostatistics Program, School of Public Health Louisiana State University Health Sciences Center New Orleans Louisiana USA

2. Department of Pharmacology and Experimental Therapeutics Louisiana State University Health Sciences Center New Orleans Louisiana USA

3. Section of Infection Diseases, Department of Medicine, School of Medicine Louisiana State University Health Sciences Center New Orleans Louisiana USA

Abstract

AbstractHuman papillomavirus (HPV) infection is a major cause of cervical cancer. Studies showed HPV carcinogenesis may be induced by oxidative stress affecting the host immune system. The objective of this study is to evaluate levels of four circulating oxidative stress biomarkers associated with the HPV infection, persistence, and cervical lesion status in women. The three serum biomarkers measuring oxidative damage to biomolecules (8‐oxodG, 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine [8‐oxodG] for DNA, 4‐hydroxy‐2‐nonenal [4‐HNE] for lipid, and protein carbonyl [PC] for protein) and one antioxidant (glutathione, GSH) collected from 38 women were evaluated. The PC levels were significantly higher for women with oncogenic HPV infection (p = 0.047) and persistence (p = 0.053) based on the unadjusted linear model. In particular, women with ≥3 oncogenic HPV types had a higher PC level than those without HPV infection (p = 0.041). Women with low‐grade squamous intraepithelial lesions showed an elevated PC (p = 0.058). These trends remained similar after adjusting for age. The GSH levels were lower for women infected with ≥3 oncogenic HPV types based on age‐adjusted results (p = 0.061). This study supported that serum PC was associated with HPV infection, persistence, and cervical lesions, so it can potentially be used to monitor HPV carcinogenesis. Further large‐scale studies will be needed to confirm these findings.

Funder

National Institutes of Health

Publisher

Wiley

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