Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells

Author:

Yan Ting1,Hu Gaosheng1,Wang Anhua1,Sun Xianduo2,Yu Xiangyong1,Jia Jingming1ORCID

Affiliation:

1. School of Traditional Chinese Materia Medica; Shenyang Pharmaceutical University; Shenyang 110016 China

2. School of Traditional Chinese Medicines; Guangdong Pharmaceutical University; Guangzhou 510006 China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology

Reference34 articles.

1. TGF-β1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspases;Al-Azayzih;Biochemical and Biophysical Research Communications,2012

2. Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: Discord in the death receptor family;Azijli;Cell Death and Differentiation,2013

3. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles;Biederbick;European Journal of Cell Biology,1995

4. Mutated BCRABL generates immunogenic T-cell epitopes in CML patients;Cai;Clinical Cancer Research,2012

5. Two new compounds from the roots and rhizomes of Trillium tschonoskii Maxim;Chai;Phytochemistry Letters,2014

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