In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity

Author:

Xu Ziyang12,Wise Megan C.3,Chokkalingam Neethu1,Walker Susanne1,Tello‐Ruiz Edgar1,Elliott Sarah T. C.1,Perales‐Puchalt Alfredo1,Xiao Peng1,Zhu Xizhou1,Pumroy Ruth A.2,Fisher Paul D.3,Schultheis Katherine3,Schade Eric3,Menis Sergey456,Guzman Stacy1,Andersen Hanne7,Broderick Kate E.3,Humeau Laurent M.3,Muthumani Kar1,Moiseenkova‐Bell Vera2,Schief William R.4568,Weiner David B.1,Kulp Daniel W.19ORCID

Affiliation:

1. The Vaccine and Immunotherapy Center The Wistar Institute Philadelphia PA 19104 USA

2. Department of Pharmacology Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA

3. Inovio Pharmaceuticals Plymouth Meeting Philadelphia PA 19422 USA

4. Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA 92037 USA

5. IAVI Neutralizing Antibody Center The Scripps Research Institute La Jolla CA 92037 USA

6. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery The Scripps Research Institute La Jolla CA 92037 USA

7. Bioqual Rockville MD 20852 USA

8. Ragon Institute of MGH MIT and Harvard Cambridge MA 02139 USA

9. Department of Microbiology Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA

Funder

W. W. Smith Charitable Trust

Norges Idrettshøgskole

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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