DoE‐assisted development and validation of a stability‐indicating HPLC‐DAD method for simultaneous determination of five cannabinoids in Cannabis sativa L. based on analytical quality by design (AQbD) concept

Author:

de Souza Maíra Ribeiro123ORCID,Koetz Mariana2,Limberger Renata Pereira1ORCID,Henriques Amélia Teresinha2ORCID

Affiliation:

1. Laboratório de Análises e Pesquisas em Toxicologia, Faculdade de Farmácia Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre RS Brazil

2. Laboratório de Farmacognosia e Controle da Qualidade de Fitoterápicos, Faculdade de Farmácia Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre RS Brazil

3. Agência Nacional de Vigilância Sanitária (ANVISA) Brasília DF Brazil

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Agência Nacional de Vigilância Sanitária

Publisher

Wiley

Subject

Complementary and alternative medicine,Drug Discovery,Plant Science,Molecular Medicine,General Medicine,Biochemistry,Food Science,Analytical Chemistry

Reference47 articles.

1. World Health Organization.Cannabis and Cannabis Resin. Report of the Thirty‐sixth Meeting of the WHO Expert Committee on Drug Dependence.;2014.

2. Cannabinoids for Medical Use

3. Review on clinical studies with cannabis and cannabinoids 2010‐2014;Kowal M;Mult Scler,2016

4. Cannabis Inflorescence for Medical Purposes: USP Considerations for Quality Attributes

5. Analytical quality by design: Development and control strategy for a LC method to evaluate the cannabinoids content in cannabis olive oil extracts

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