Clinical factor‐based risk stratification for precision therapy in locally advanced squamous cell carcinoma of the uterine cervix

Author:

Liu Feng‐Yuan123ORCID,Chen Wei‐Chun345ORCID,Pan Yu‐Bin6ORCID,Wang Chun‐Chieh37,Tang Yun‐Hsin35,Chou Hung‐Hsueh235,Chao Angel35ORCID,Yang Lan‐Yan6ORCID,Lai Chyong‐Huey35ORCID

Affiliation:

1. Department of Nuclear Medicine and Molecular Imaging Center Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine Taoyuan Taiwan

2. School of Medicine, National Tsing Hua University Hsinchu Taiwan

3. Gynecologic Cancer Research Center Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine Taoyuan Taiwan

4. Department of Obstetrics and Gynecology New Taipei City Municipal Tucheng Hospital New Taipei City Taiwan

5. Department of Obstetrics and Gynecology Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine Taoyuan Taiwan

6. Clinical Trial Center, Chang Gung Memorial Hospital Taoyuan Taiwan

7. Department of Radiation Oncology Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine Taoyuan Taiwan

Abstract

AbstractBackgroundConcurrent chemoradiotherapy (CCRT) is the standard of care for locally advanced cervical cancer. In this study, we analyzed the pretreatment clinical and 18F‐fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) characteristics of patients with locally advanced cervical squamous cell carcinoma (SCC) to develop a scoring prototype for risk stratification.MethodsTwo cohorts were constructed in this study. Cohort 1 comprised patients with cervical SCC with 2009 FIGO stage III‐IVA or stage I–II with positive pelvic or para‐aortic lymph node (PALN) on PET/CT from AGOG09‐001 trial. Cohort 2 comprised patients with similar characteristics who had received adequate therapy in our hospital between 2016 and 2021. Pretreatment patient characteristics and PET/CT parameters including maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) of primary tumor and nodal SUVmax were assessed for cancer‐specific survival (CSS) using multivariate Cox regression.ResultsAnalysis of combined data from cohorts 1 (n = 55) and 2 (n = 128) indicated age ≥ 66 years, primary tumor MTV ≥87 mL, and positive PALN on PET/CT to be independently significant adverse predictors for CSS (p < 0.001, p = 0.014, and p = 0.026, respectively) with a median follow‐up duration of 51 months. Assigning a score of 1 to each adverse predictor, patients with cumulative risk scores of 0, 1, 2, and 3 were discovered to have a 5‐year CSS of 86.9%, 71.0%, 32.2%, and 0%, respectively (p < 0.001).ConclusionAge, primary tumor MTV, and positive PALN on PET/CT may serve as independent predictors of poor survival in patients with locally advanced cervical SCC. Our findings indicate that patients without any adverse factors can receive standard CCRT, whereas those with at least one adverse factor can consider novel combination therapies or clinical trials.

Funder

Chang Gung Medical Foundation

Ministry of Health and Welfare

Publisher

Wiley

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