Affiliation:
1. Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute Queen Mary University of London, London, United Kingdom
Abstract
Abstract
Pancreatic cancer stem cells (CSCs) have been first described in 2007 and since then have emerged as an intriguing entity of cancer cells with distinct functional features including self-renewal and exclusive in vivo tumorigenicity. The heterogeneous pancreatic CSC pool has been implicated in tumor propagation as well as metastatic spread. Clinically, the most important feature of CSCs is their strong resistance to standard chemotherapy, which results in fast disease relapse, even with today's more advanced chemotherapeutic regimens. Therefore, novel therapeutic strategies to most efficiently target pancreatic CSCs are being developed and their careful clinical translation should provide new avenues to eradicate this deadly disease. Stem Cells 2015;33:2893—2902
Funder
ERC Advanced Investigator Grant
European Community's Seventh Framework Programme
under grant agreement n°
National Charity Pancreatic Cancer U.K
Publisher
Oxford University Press (OUP)
Subject
Cell Biology,Developmental Biology,Molecular Medicine
Cited by
33 articles.
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