Structural mapping of the ClpBATPases ofPlasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design

Author:

AhYoung Andrew P.1,Koehl Antoine1,Cascio Duilio2,Egea Pascal F.13

Affiliation:

1. Department of Biological Chemistry; David Geffen School of Medicine; UCLA; Los Angeles California

2. Department of Energy Institute for Genomics and Proteomics; UCLA; Los Angeles California

3. Molecular Biology Institute, UCLA; Los Angeles California

Funder

National Center for Research Resources

National Institute of General Medical Sciences

DOE Integrated Diffraction Analysis (IDAT)

National Institutes of Health

UCLA Geffen School of Medicine

UCLA Scholars in Translational Medicine Program Award

Alexander and Renée Kolin Endowed Professorship in Molecular Biology and Biophysics

National Center for Advancing Translational Sciences UCLA CTSI

Gates Millennium and Dissertation of the Year fellowships

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Reference72 articles.

1. Organization, function and substrates of the essential Clp protease system in plastids;Nishimura;Biochim Biophys Acta,2014

2. AAA+: a class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes;Neuwald;Genome Res,1999

3. Hsp104 and ClpB: protein disaggregating machines;Doyle;Trend Biochem Sci,2009

4. ClpXP, an ATP-powered unfolding and protein-degradation machine;Baker;Biochim Biophys Acta,2012

5. ClpP: a distinctive family of cylindrical energy-dependent serine proteases;Yu;FEBS Lett,2007

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