Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site-Reference-Cited by-同舟云学术

Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site

Published:2018-04-10 Issue:8 Volume:86 Page:833-843
ISSN:0887-3585
Container-title:Proteins: Structure, Function, and Bioinformatics
language:en
Short-container-title:Proteins

Author:

Molinski Steven V.¹^ORCID,Shahani Vijay M.¹,Subramanian Adithya S.¹,MacKinnon Stephen S.¹,Woollard Geoffrey¹,Laforet Marcon¹,Laselva Onofrio²,Morayniss Leonard D.¹,Bear Christine E.²³⁴,Windemuth Andreas¹^ORCID

Affiliation:

1. Cyclica Inc.; Toronto Ontario M5C 1C4 Canada

2. Programme in Molecular Structure and Function; Research Institute, Hospital for Sick Children; Toronto Ontario M5G 0A4 Canada

3. Department of Physiology; University of Toronto; Toronto Ontario M5S 1A8 Canada

4. Department of Biochemistry; University of Toronto; Toronto Ontario M5S 1A8 Canada

Publisher

Wiley

Subject

Molecular Biology,Biochemistry,Structural Biology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/prot.25496/fullpdf

Reference41 articles.

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3. Cystic fibrosis;Rowe;N Engl J Med.,2005

4. A new era in the treatment of cystic fibrosis: correction of the underlying CFTR defect;Boyle;Lancet Respir Med.,2013

5. VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface;Eckford;Chem Biol.,2014

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