Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling

Author:

Han Y.12,Jiang C.34,Tang J.3,Wang C.2,Wu P.2,Zhang G.4,Liu W.23,Jamangulova N.5,Wu X.6,Song X.1

Affiliation:

1. Department of Anesthesiology; Xijing Hospital; Fourth Military Medical University; Xi'an Shanxi China

2. Jiangsu Province Key Laboratory of Anesthesiology; Xuzhou Medical College; Xuzhou Jiangsu China

3. Jiangsu Key Laboratory of Neurodegeneration; Department of Pharmacology; Nanjing Medical University; Nanjing China

4. Research Division of Pharmacology; China Pharmaceutical University; Nanjing Jiangsu China

5. Department of International Education; Nanjing University; Nanjing Jiangsu China

6. State Key Laboratory of Pharmaceutical Biotechnology; Nanjing University; Nanjing Jiangsu China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Anesthesiology and Pain Medicine

Reference49 articles.

1. Distribution of [3H]trans-resveratrol in rat tissues following oral administration;Abd El-Mohsen;Br J Nutr,2006

2. Metabolites and tissue distribution of resveratrol in the pig;Azorin-Ortuno;Mol Nutr Food Res,2011

3. Morphine: Axon regeneration, neuroprotection, neurotoxicity, tolerance, and neuropathic pain;Berrios;P R Health Sci J,2008

4. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus;Blasi;J Neuroimmunol,1990

5. Morphine enhances Tat-induced activation in murine microglia;Bokhari;J Neurovirol,2009

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