Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3‐selective GABAkine KRM‐II‐81-Reference-Cited by-同舟云学术

Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3‐selective GABAkine KRM‐II‐81

Published:2022-03-10 Issue:2 Volume:43 Page:66-75
ISSN:0142-2782
Container-title:Biopharmaceutics & Drug Disposition
language:en
Short-container-title:Biopharm & Drug Disp

Author:

Golani Lalit K.¹^ORCID,Divović Branka²,Sharmin Dishary¹,Pandey Kamal P.¹,Mian Md Yeunus¹,Cerne Rok³⁴⁵⁶,Zahn Nicolas M.¹,Meyer Michelle J.¹,Tiruveedhula Veera V. N. P. B.¹,Smith Jodi L.³,Ping Xingjie⁴,Jin Xiaoming⁴,Lippa Arnold⁶,Schkeryantz Jeffrey M.⁷,Arnold Leggy A.¹^ORCID,Cook James M.¹⁶,Savić Miroslav M.²,Witkin Jeffrey M.¹³⁶^ORCID

Affiliation:

1. Department of Chemistry & Biochemistry Milwaukee Institute of Drug Discovery University of Wisconsin‐Milwaukee Milwaukee Wisconsin USA

2. Department of Pharmacology Faculty of Pharmacy University of Belgrade Belgrade Serbia

3. Laboratory of Antiepileptic Drug Discovery Ascencion St. Vincent Indianapolis Indiana USA

4. Department of Anatomy and Cell Biology Indiana University/Purdue University Indianapolis Indiana USA

5. Faculty of Medicine University of Ljubljana Ljubljana Slovenia

6. RespireRx Pharmaceuticals Inc Glen Rock New Jersey USA

7. Bristol Myers Squibb Cambridge Massachusetts USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bdd.2313

Reference21 articles.

1. The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development

2. GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

3. Exposure to a Deuterated Analogue of Phenylbutyrate Retards S-Phase Progression in HT-29 Colon Cancer Cells

4. Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

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