Loss of FBXO7 results in a Parkinson's‐like dopaminergic degeneration via an RPL23–MDM2

Loss of FBXO7 results in a Parkinson's‐like dopaminergic degeneration via an RPL23–MDM2–TP53 pathway

Published:2019-08-06 Issue:2 Volume:249 Page:241-254
ISSN:0022-3417
Container-title:The Journal of Pathology
language:en
Short-container-title:J. Pathol.

Author:

Stott Simon RW¹,Randle Suzanne J²,Rawi Sara²,Rowicka Paulina A²,Harris Rebecca²,Mason Bethany²,Xia Jing³,Dalley Jeffrey W³⁴,Barker Roger A¹⁵,Laman Heike²^ORCID

Affiliation:

1. John van Geest Centre for Brain RepairUniversity of Cambridge Cambridge UK

2. Department of PathologyUniversity of Cambridge Cambridge UK

3. Behavioural and Clinical Neuroscience Institute and Department of PsychologyUniversity of Cambridge Cambridge UK

4. Department of PsychiatryUniversity of Cambridge Cambridge UK

5. Wellcome – MRC Stem Cell InstituteUniversity of Cambridge Cambridge UK

Funder

Biotechnology and Biological Sciences Research Council

Parkinson's UK

Wellcome Trust

University of Cambridge

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/path.5312

Reference44 articles.

1. Epidemiology of Parkinson's disease

2. Genetics of Parkinson's disease

3. Parkinsonâ€™s disease: animal models and dopaminergic cell vulnerability

4. Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins

5. Genome-wide Linkage Analysis of a Parkinsonian-Pyramidal Syndrome Pedigree by 500 K SNP Arrays

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Gene Signals and SNPs Associated with Parkinson’s Disease: A Nutrigenomics and Computational Prospective Insights;Neuroscience;2023-11

2. Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners;Journal of Biological Chemistry;2023-06

3. The characteristics of FBXO7 and its role in human diseases;Gene;2023-01

4. Progress in Parkinson's disease animal models of genetic defects: Characteristics and application;Biomedicine & Pharmacotherapy;2022-11

5. Impaired mitochondrial accumulation and Lewy pathology in neuron-specific FBXO7-deficient mice;Molecular Brain;2022-06-14