Atmospheric solids analysis probe mass spectrometry: An easy bolt‐on for the synthetic undergraduate teaching laboratory

Abstract

RationaleHigh costs and student numbers can often hinder implementation of mass spectrometry (MS) in the undergraduate teaching laboratory, often with technicians running samples on students' behalf, and the implementation of MS only in discrete or isolated experiments. This study explores the use of atmospheric solids analysis probe MS (ASAP‐MS) as a relatively low‐cost, benchtop instrument, and its potential for application as a ‘bolt‐on’ to existing undergraduate organic chemistry experiments.MethodsThirteen products synthesised in undergraduate laboratory experiments were analysed by ASAP‐MS, along with their starting materials. Analysis was carried out with a Waters RADIAN ASAP mass spectrometer, at four different cone voltages simultaneously to provide fragmentation information.ResultsOut of the 13 undergraduate experiments, ASAP‐MS was shown to be complementary in 11 of these, either through simple analysis of the precursor ion or by a more complex analysis of the fragments.ConclusionsASAP‐MS provided spectra that both complement and enhance intended learning outcomes in existing organic chemistry experiments, showing its versatility as a bolt‐on technique. Moving forward, ASAP‐MS will be integrated into the University of Surrey's undergraduate teaching laboratory.