Outcome of children and adolescents with Down syndrome treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium protocols 00-001 and 05-001

Author:

Athale Uma H.1ORCID,Puligandla Maneka2,Stevenson Kristen E.2,Asselin Barbara3,Clavell Luis A.4,Cole Peter D.5,Kelly Kara M.6,Laverdiere Caroline7,Leclerc Jean-Marie7,Michon Bruno8,Schorin Marshall A.9,Sulis Maria Luisa10,Welch Jennifer J. G.11ORCID,Harris Marian H.12,Neuberg Donna S.2ORCID,Sallan Stephen E.13,Silverman Lewis B.13

Affiliation:

1. Division of Hematology/Oncology; McMaster Children's Hospital; Hamilton Health Sciences; Hamilton ON Canada

2. Department of Biostatistics and Computational Biology; Dana-Farber Cancer Institute; Boston MA USA

3. Department of Pediatrics; University of Rochester Medical Center and School of Medicine; Rochester NY USA

4. Department of Pediatrics; San Jorge Children's Hospital; San Juan; Puerto Rico

5. Pediatrics; Montefiore Medical Center; Albert Einstein College of Medicine; Bronx NY USA

6. Department of Pediatric Oncology; Roswell Park Comprehensive Cancer Center; Division of Pediatric Hematology/Oncology; Jacob's School of Medicine and Biomedical Sciences, University of Buffalo; NY USA

7. Hematology-Oncology Division; Charles Bruneau Cancer Center; Sainte-Justine University Hospital; University of Montreal; Montreal QC Canada

8. Pediatrics; Centre Hospitalier Universitaire de Quebec; Sainte-Foy; QC Canada

9. Pediatrics; Inova Fairfax Hospital for Children; Falls Church VA USA

10. Division of Pediatric Hematology/Oncology/Stem Cell Transplantation; Columbia University Medical Center; New York USA

11. Pediatric Hematology Oncology; Hasbro Children's Hospital/Brown University; Providence RI USA

12. Department of Pathology; Boston Children's Hospital; Boston MA USA

13. Department of Pediatric Oncology; Dana-Farber Cancer Institute and Division of Pediatric Hematology-Oncology; Boston Children's Hospital; Boston MA USA

Funder

National Cancer Institute

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference25 articles.

1. Epidemiology of leukemia in children with Down syndrome;Ross;Pediatr Blood Cancer,2005

2. Risks of leukemia and solid tumors in individuals with Down's syndrome;Hasle;Lancet,2000

3. Lymphoblast biology and outcome among children with Down syndrome and ALL treated on CCG-1952;Bassal;Pediatr Blood Cancer,2005

4. Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study;Forestier;Blood,2018

5. Down syndrome childhood acute leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: a report from Children's Oncology Group;Maloney;Blood,2010

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