A Novel Strategy for ADME Screening of Prodrugs: Combined Use of Serum and Hepatocytes to Integrate Bioactivation and Clearance, and Predict Exposure to Both Active and Prodrug to the Systemic Circulation-Reference-Cited by-同舟云学术

A Novel Strategy for ADME Screening of Prodrugs: Combined Use of Serum and Hepatocytes to Integrate Bioactivation and Clearance, and Predict Exposure to Both Active and Prodrug to the Systemic Circulation

Published:2014-05 Issue:5 Volume:103 Page:1504-1514
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Hoppe Edmund,Hewitt Nicola J.,Buchstaller Hans-Peter,Eggenweiler Hans-Michael,Sirrenberg Christian,Zimmermann Astrid,März Joachim,Schwartz Harry,Saal Christoph,Meyring Michael,Hecht Stefan

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference33 articles.

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5. Drug absorption studies of prodrug esters using the Caco-2 model: Evaluation of ester hydrolysis and transepithelial transport;Augustijns;Int J Pharm,1988

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