Induction of Cbl-dependent epidermal growth factor receptor degradation in Ling Zhi-8 suppressed lung cancer

Author:

Lin Tung-Yi12ORCID,Hsu Hsien-Yeh123ORCID,Sun Wei-Hsuan2,Wu Tsung-Han2,Tsao Shu-Ming2

Affiliation:

1. Program in Molecular Medicine, National Yang-Ming University and Academia Sinica; Taipei Taiwan

2. Department of Biotechnology and Laboratory Science in Medicine; National Yang-Ming University; Taipei Taiwan

3. The Genomics Research Center, Academia Sinica; Taipei Taiwan

Funder

Ministry of Science and Technology

National Yang-Ming University (Ministry of Education, Aim for the Top University Plan), Taiwan

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference36 articles.

1. Ling-Zhi-8: a fungal protein with immunomodulatory effects;Hem;Transpl Proc,1996

2. Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway;Wu;Carcinogenesis,2011

3. Reishi protein LZ-8 induces FOXP3(1) Treg expansion via a CD45-dependent signaling pathway and alleviates acute intestinal inflammation in mice;Hsu;Evid Based Complement Alternat Med

4. Isolation and characterization of a new immunomodulatory protein, ling zhi-8 (LZ-8), from Ganoderma lucidum;Kino;J Biol Chem,1989

5. Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidum;Huang;Proteins,2009

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