Omics insights into the responses to dietary selenium

Author:

Arias‐Borrego Ana12,Callejón‐Leblic Belén1,Collado Maria Carmen3,Abril Nieves4,García‐Barrera Tamara1ORCID

Affiliation:

1. Research Center of Natural Resources, Health and the Environment (RENSMA), Department of Chemistry, Faculty of Experimental Sciences, University of Huelva Fuerzas Armadas Ave. Huelva Spain

2. Department of Analytical Chemistry, Faculty of Chemistry, University of Sevilla Profesor García González Ave. Seville Spain

3. Department of Biotechnology Institute of Agrochemistry and Food Technology‐National Research Council (IATA‐CSIC) Paterna Valencia Spain

4. Department of Biochemistry and Molecular Biology, University of Córdoba, Campus de Rabanales Edificio Severo Ochoa Córdoba Spain

Abstract

AbstractSelenium is a well‐known health‐relevant element related with cancer chemoprevention, neuroprotective roles, beneficial in diabetes, and in several infectious diseases, among others. It is naturally present in some foods, but deficiency in people led to the production of nutraceuticals, supplements, and functional food enriched in this element. There is a U‐shaped link between selenium levels and health and a narrow range between toxic and essential levels, and thus, supplementation should be performed carefully. Omics methodologies have become valuable approaches to delve into the responses of dietary selenium in mammals that allowed a deeper knowledge about the metabolism of this element as well as its biological role. In this review, we discuss omics approaches from the workflows to their applications that has been previously used to deep insight into the metabolism of dietary selenium. There is a special focus on selenoproteins, metabolomics responses in blood and tissues (e.g., brain, reproductive organs, etc.) as well as the impact on gut microbiota and its metabolites profile. Thus, we mainly reviewed heteroatom‐tagged proteomics, metallomics, metabolomics, and metataxonomics, usually combined with transcriptomics, genomics, and other molecular methods.

Funder

Ministerio de Ciencia e Innovación

Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

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