Bone Marrow Therapies for Chronic Heart Disease

Author:

Behbahan Iman Saramipoor1,Keating Armand2,Gale Robert Peter3

Affiliation:

1. Clinical Observer, Division of Hematology, Stanford MDS Center Stanford University, Palo Alto, California, USA

2. Division of Hematology University of Toronto, Cell Therapy Program, Princess Margaret Hospital, Toronto, Canada

3. Section of Haematology, Division of Medicine, Department of Medicine Imperial College London, London, United Kingdom

Abstract

Abstract Chronic heart failure is a leading cause of death. The demand for new therapies and the potential regenerative capacity of bone marrow-derived cells has led to numerous clinical trials. We critically discuss current knowledge of the biology and clinical application of bone marrow cells. It appears unlikely that bone marrow cells can develop into functional cardiomyocyte after infusion but may have favorable paracrine effects. Most, but not all, clinical trials report a modest short- but not long-term benefit of infusing bone marrow-derived cells. Effect size appears to correlate with stringency of study-design: the most stringent trials report the smallest effect-sizes. We conclude there may be short- but not substantial long-term benefit of infusing bone marrow-derived cells into persons with chronic heart failure and any benefit observed is unlikely to result from trans-differentiation of bone marrow-derived cells into functioning cardiomyocytes. Stem Cells  2015;33:3212–3227

Funder

National Institute for Health Research

Biomedical Research Centre funding scheme

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,Molecular Medicine

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