Development and validation of a simple, sensitive and accurate LC-MS/MS method for the determination of guanfacine, a selectiveα2A-adrenergicreceptor agonist, in plasma and its application to a pharmacokinetic study

Author:

Li Xiaonan1,Li Ning1,Sun Xiaolin1,Yang Wei1,Dai Yu1,Xu Jie1,Zhang Wei1,Wang Chunfeng1,Wang Suilou1,Chen Xijing1

Affiliation:

1. College of Pharmacy; China Pharmaceutical University; Nanjing 210009 People's Republic of China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference23 articles.

1. The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder;Arnsten;Expert Review of Neurotherapeutics,2010

2. Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale;Arnsten;The Yale Journal of Biology and Medicine,2012

3. A randomized, double-blind, placebo-controlled study of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity;Biederman;Pediatrics,2008

4. Guanfacine extended release as adjunctive therapy to psychostimulants in children and adolescents with attention-deficit/hyperactivity disorder;Childress;Advances in Therapy,2012

5. Effects of guanfacine extended release on oppositional symptoms in children aged 6-12 years with attention-deficit hyperactivity disorder and oppositional symptoms: a randomized, double-blind, placebo-controlled trial;Connor;CNS Drugs,2010

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