18F‐sodium fluoride positron emission tomography quantitation of bone metastases in African American and non‐African American men with metastatic prostate cancer

Abstract

AbstractBackgroundBone is the most common site of metastases in men with prostate cancer. The objective of this study was to explore potential racial differences in the distribution of tumor metastases in the axial and appendicular skeleton.MethodsWe conducted a retrospective review of patients with metastatic prostate cancer to the bone as detected by 18F‐sodium fluoride positron emission tomography/computed tomography (18F‐NaF PET/CT) scans. In addition to describing patients' demographics and clinical characteristics, the metastatic bone lesions, and healthy bone regions were detected and quantified volumetrically using a quantitative imaging platform (TRAQinform IQ, AIQ Solutions).ResultsForty men met the inclusion criteria with 17 (42%) identifying as African Americans and 23 (58%) identifying as non‐African Americans. Most of the patients had axial (skull, ribcage, and spine) disease. The location and the number of lesions in the skeleton of metastatic prostate cancer patients with low disease burden were not different by race.ConclusionsIn low‐disease burden patients with metastatic prostate cancer, there were no overall differences by race in the location and number of lesions in axial or appendicular skeleton. Therefore, given equal access to molecular imaging, African Americans might derive similar benefits. Whether this holds true for patients with a higher disease burden or for other molecular imaging techniques is a topic for further study.