Peritumoral MRI Radiomics Features Increase the Evaluation Efficiency for Response to Chemotherapy in Patients With Epithelial Ovarian Cancer

Abstract

BackgroundIt remains unclear whether extracting peritumoral volume (PTV) radiomics features are useful tools for evaluating response to chemotherapy of epithelial ovarian cancer (EOC).PurposeTo evaluate MRI radiomics signatures (RS) capturing subtle changes of PTV and their added evaluation performance to whole tumor volume (WTV) for response to chemotherapy in patients with EOC.Study TypeRetrospective.Population219 patients aged from 15 to 79 years were enrolled.Field Strength/Sequence3.0 or 1.5T, axial fat‐suppressed T2‐weighted imaging (FS‐T2WI), diffusion‐weighted imaging (DWI), and contrast enhanced T1‐weighted imaging (CE‐T1WI).AssessmentMRI features were extracted from the four axial sequences and six different volumes of interest (VOIs) (WTV and WTV + PTV (WPTV)) with different peritumor sizes (PS) ranging from 1 to 5 mm. Those features underwent preprocessing, and the most informative features were selected using minimum redundancy maximum relevance and least absolute shrinkage and selection operator to construct the RS. The optimal RS, with the highest area under the curve (AUC) of receiver operating characteristic was then integrated with independent clinical characteristics through multivariable logistic regression to construct the radiomics‐clinical model (RCM).Statistical TestsMann–Whitney U test, chi‐squared test, DeLong test, log‐rank test. P < 0.05 indicated a significant difference.ResultsAll the RSs constructed on WPTV exhibited higher AUCs (0.720–0.756) than WTV (0.671). Of which, RS with PS = 2 mm displayed a significantly better performance (AUC = 0.756). International Federation of Gynecology and Obstetrics (FIGO) stage was identified as the exclusive independent clinical evaluation characteristic, and the RCM demonstrated higher AUC (0.790) than the RS, but without statistical significance (P = 0.261).Data ConclusionThe radiomics features extracted from PTV could increase the efficiency of WTV radiomics for evaluating the chemotherapy response of EOC. The cut‐off of 2 mm PTV was a reasonable value to obtain effective evaluation efficiency.Level of Evidence4Technical EfficacyStage 2