Affiliation:
1. Department of Head and Neck Cancer Health Research Institute of the Principality of Asturias Oviedo Spain
2. Department of Otolaryngology Hospital Universitario Central de Asturias Oviedo Spain
3. Department of Pathology Hospital Universitario Central de Asturias Oviedo Spain
Abstract
AbstractBackgroundRecurrent intestinal‐type sinonasal adenocarcinoma (ITAC) can occur several years after primary treatment and with different histology. We aimed to clarify if such recurrences could be second primary tumors and to identify actionable mutations as targets for personalized treatment of recurrent ITAC.MethodsTwelve pairs of primary and recurrent ITAC were histologically examined and analyzed by next‐generation sequencing.ResultsHistological differences between primary and recurrent tumor pairs were observed in five cases. Frequent mutations included TP53, APC, TSC2, ATM, EPHA2, BRCA2, LRP1B, KRAS, and KMT2B. There was 86% concordance of somatic mutations between the tumor pairs, while four cases carried additional mutations in the recurrence.ConclusionsWe found all cases to be clonal recurrences and not second primary tumors. Moreover, tumor pairs showed a remarkable genomic stability, suggesting that personalized treatment of a recurrence may be based on actionable molecular genetic targets observed in the primary tumor.
Funder
Instituto de Salud Carlos III
Gobierno del Principado de Asturias