A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation inGDF6That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal-Reference-Cited by-同舟云学术

A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation inGDF6That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal

Published:2015-12-28 Issue:4 Volume:31 Page:882-889
ISSN:0884-0431
Container-title:Journal of Bone and Mineral Research
language:en
Short-container-title:J Bone Miner Res

Author:

Wang Jian¹,Yu Tingting¹,Wang Zhigang²,Ohte Satoshi³,Yao Ru-en¹,Zheng Zhaojing¹,Geng Juan¹,Cai Haiqing²,Ge Yihua²,Li Yuchan²,Xu Yunlan²,Zhang Qinghua⁴,Gusella James F⁵,Fu Qihua¹,Pregizer Steven³,Rosen Vicki³,Shen Yiping¹⁶⁷

Affiliation:

1. Department of Laboratory Medicine; Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine; Shanghai PR China

2. Department of Pediatric Orthopedics; Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine; Shanghai PR China

3. Developmental Biology; Harvard School of Dental Medicine; Boston MA USA

4. State Key Laboratory of Medical Genomics; Ruijin Hospital, Shanghai Jiaotong University School of Medicine; Shanghai PR China

5. Molecular Neurogenetics Unit and Center for Human Genetic Research; Massachusetts General Hospital and Harvard Medical School; Boston MA USA

6. Department of Laboratory Medicine; Boston Children's Hospital; Boston MA USA

7. Claritas Genomics; Cambridge MA USA

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jbmr.2761/fullpdf

Reference37 articles.

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3. BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways;Yoon;Development,2006

4. Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity;Baur;Development,2000

5. The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development;Rigueur;J Bone Miner Res,2015

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