Intratumoral activation of cyclophosphamide by retroviral transfer of the cytochrome P450 2B1 in a pancreatic tumor model. Combination with the HSVtk/GCV system

Author:

Carrió Meritxell,Visa Joana,Cascante Anna,Estivill Xavier,Fillat Cristina

Funder

Fundació Marató de TV3

CICYT

Servei Català de la Salut

Publisher

Wiley

Subject

Genetics(clinical),Drug Discovery,Genetics,Molecular Biology,Molecular Medicine

Reference33 articles.

1. Pancreatic carcinoma;Warshaw;N Engl J Med,1992

2. Pancreatic cancer: a review of emerging therapies;Rosenberg;Drugs,2000

3. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy;Moolten;Cancer Res,1986

4. Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1;Cheng;Proc Natl Acad Sci U S A,1983

5. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy;Bi;Hum Gene Ther,1993

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