A combined screening and in silico strategy for the rapid design of integrated downstream processes for process and product‐related impurity removal-Reference-Cited by-同舟云学术

A combined screening and in silico strategy for the rapid design of integrated downstream processes for process and product‐related impurity removal

Published:2019-06-29 Issue:9 Volume:116 Page:2178-2190
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnology and Bioengineering

Author:

Vecchiarello Nicholas¹,Timmick Steven M.¹,Goodwine Chaz¹,Crowell Laura E.²³,Love Kerry R.²³,Love J. Christopher²³,Cramer Steven M.¹^ORCID

Affiliation:

1. Department of Chemical and Biological Engineering Rensselaer Polytechnic Institute Center for Biotechnology and Interdisciplinary Studies Troy New York

2. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge Massachusetts

3. Department of Chemical Engineering Massachusetts Institute of Technology Cambridge Massachusetts

Funder

Defense Advanced Research Projects Agency

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27018

Reference41 articles.

1. Design and control of integrated chromatography column sequences

2. Determinants of protein elution rates from preparative ion-exchange adsorbents

3. Is there a rational method to purify proteins? From expert systems to proteomics

4. Development of an expert system for selection and synthesis of protein purification processes

5. A novel multimodal chromatography based single step purification process for efficient manufacturing of an E. coli based biotherapeutic protein product

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