Development and validation of a simple and sensitive high‐resolution LC/MS method for determination of PF‐04620110 in dog plasma: Application to a pharmacokinetic study-Reference-Cited by-同舟云学术

Development and validation of a simple and sensitive high‐resolution LC/MS method for determination of PF‐04620110 in dog plasma: Application to a pharmacokinetic study

Published:2019-07-11 Issue:9 Volume:33 Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

He Fan¹^ORCID,Zheng Wei¹,Chen Yongzhuang¹,Mo Chengke¹,Chen Yilu¹

Affiliation:

1. Guangzhou Women and Children's Medical Center Guangzhou China

Funder

Science and Technology Planning Project of Guangdong Province

National Natural Science Foundation of China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.4562

Reference13 articles.

1. Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases

2. Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members

3. Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor

4. Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

5. Modeling the Mechanism of Action of a DGAT1 Inhibitor Using a Causal Reasoning Platform

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