Affiliation:
1. Department of Head and Neck Surgical Oncology University Medical Center Utrecht Utrecht The Netherlands
2. Department of Pathology University Medical Center Utrecht Utrecht The Netherlands
Abstract
AbstractBackgroundThe adequate surgical margin for local control of buccal mucosa squamous cell carcinoma (BMSCC) is under debate. This study investigates surgical margins and other factors associated with local recurrence free survival (LRFS) in a large cohort of BMSCC patients.MethodsMultiple factors were evaluated retrospectively in 97 patients with BMSCC. Cox‐regression and Kaplan–Meier curves were used for analysis.ResultsThe local recurrence rate was 23%. The tumor‐free margin was <5.0 mm in 89% of the patients and the deep margin was significantly more often inadequate. Multivariate analysis associated pT3‐classification, former smokers, tumor‐free margin status, and postoperative (chemo)radiation (PO(ch)RT) with local recurrence. Re‐resections did not improve LRFS in patients with <5.0 mm tumor‐free margins.ConclusionsAdequate tumor‐free margins are pivotal for LRFS of BMSCC. PO(ch)RT, not re‐resection, can improve LRFS in patients with <5.0 mm tumor‐free margins.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献