Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability-Reference-Cited by-同舟云学术

Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability

Published:2017-03-06 Issue:6 Volume:114 Page:1264-1274
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnol. Bioeng.

Author:

Chung Wai Keen¹^ORCID,Russell Brian²,Yang Yanhong³,Handlogten Michael⁴,Hudak Suzanne⁵,Cao Mingyan³,Wang Jihong³,Robbins David¹,Ahuja Sanjeev²^ORCID,Zhu Min⁶

Affiliation:

1. Purification Process Sciences; MedImmune LLC; One MedImmune Way; Gaithersburg Maryland

2. Cell Culture and Fermentation Sciences; MedImmune LLC; One MedImmune Way; Gaithersburg Maryland

3. Analytical Sciences; MedImmune LLC; One MedImmune Way; Gaithersburg Maryland

4. Cell Culture Sciences; Macrogenics Inc; Rockville Maryland

5. Formulation Sciences; MedImmune LLC; One MedImmune Way; Gaithersburg Maryland

6. Protein Science; Boehringer Ingelheim Fremont Inc; Fremont California

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference19 articles.

1. Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression;Buchanan;MAbs,2013

2. Monoclonal antibody therapy in rheumatoid arthritis;Choy;Br J Rheumatol,1998

3. Multinational study of the efficacy and safety of humanized anti-her2 monoclonal antibody in women who have her2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease;Cobleigh;J Clin Oncol,1999

4. A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy;Fan;Breast Cancer Res,2012

5. Increased aggregation propensity of IgG2 subclass over IgG1: Role of conformational changes and covalent character in isolated aggregates;Franey;Protein Sci,2010

Cited by 40 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Stable and reusable calcium‐responsive biopolymer for affinity precipitation of therapeutic antibodies;Protein Science;2024-07-29

2. Escherichia coli and Pichia pastoris : microbial cell-factory platform for full-length IgG production;Critical Reviews in Biotechnology;2024-05-26

3. Raman Spectroscopy for Monitoring Free Sulfhydryl Formation During Monoclonal Antibody Manufacturing;2024

4. Heterogeneity in Disulfide Bond Reduction in IgG1 Antibodies Is Governed by Solvent Accessibility of the Cysteines;Antibodies;2023-12-13

5. Detecting Features of Protein Structure through their Mediator-Accessible Redox Activities;2023-12-13