Microcystin-LR disrupts insulin signaling by hyperphosphorylating insulin receptor substrate 1 and glycogen synthase-Reference-Cited by-同舟云学术

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Microcystin-LR disrupts insulin signaling by hyperphosphorylating insulin receptor substrate 1 and glycogen synthase

Published:2017-10-06 Issue:1 Volume:33 Page:16-22
ISSN:1520-4081
Container-title:Environmental Toxicology
language:en
Short-container-title:Environmental Toxicology

Author:

Liu Jinghui¹,Xu Chun²,Zhang Shaofeng²,Li Haoyan²,Chen Kele¹,Huang Pu¹,Guo Zonglou³,Xu Lihong¹

Affiliation:

1. Department of Biochemistry, School of Medicine; Zhejiang University; Hangzhou 310058 China

2. Department of Endocrinology; General Hospital of the Chinese People's Armed Police Forces; Beijing 100039 China

3. Department of Biosystem Engineering; College of Biosystem Engineering and Food Science, Zhejiang University; Hangzhou 310058 China

Funder

ST

National Nature Science Foundation of China

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Management, Monitoring, Policy and Law,Toxicology,General Medicine

Reference47 articles.

1. Selectivity and potency of microcystin congeners against OATP1B1 and OATP1B3 expressing cancer cells;Niedermeyer;PloS One.,2014

2. Molecular aspects of microcystin-induced hepatotoxicity and hepatocarcinogenesis;Svircev;J Environ Sci Health C Environ Carcinog Ecotoxicol Rev.,2010

3. Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins;Xing;Cell.,2006

4. Microcystin-LR promotes proliferation by activating Akt/S6K1 pathway and disordering apoptosis and cell cycle associated proteins phosphorylation in HL7702 cells;Liu;Toxicol Lett.,2015

5. Microcystin-LR promotes cell proliferation in the mice liver by activating Akt and p38/ERK/JNK cascades;Liu;Chemosphere.,2016

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1. Dissection of molecular mechanisms of liver injury induced by microcystin-leucine arginine via single-cell RNA-sequencing;Journal of Environmental Sciences;2024-11

2. A new identity of microcystins: Environmental endocrine disruptors? An evidence-based review;Science of The Total Environment;2022-12

3. PI3K / AKT / mTOR pathway mediated‐cell cycle dysregulation contribute to malignant proliferation of mouse spermatogonia induced by microcystin‐leucine arginine;Environmental Toxicology;2022-10-26

4. Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans;Toxins;2021-07-29

5. Update on the adverse effects of microcystins on the liver;Environmental Research;2021-04

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