Macrophage efferocytosis in health and disease

Author:

Razi Shokufeh1,Yaghmoorian Khojini Javad2,Kargarijam Fateme3,Panahi Susan4,Tahershamsi Zahra5,Tajbakhsh Amir67,Gheibihayat Seyed Mohammad28ORCID

Affiliation:

1. Department of Genetics, Faculty of Basic Sciences, Central Tehran Branch Islamic Azad University Tehran Iran

2. Department of Medical Biotechnology, School of Medicine Shahid Sadoughi University of Medical Sciences Yazd Iran

3. Department of Biotechnology, Faculty of Sciences and Advanced Technology in Biology University of Science and Culture Tehran Iran

4. Department of Microbiology, School of Medicine Shahid Sadoughi University of Medical Sciences Yazd Iran

5. Department of Biophysics, Faculty of Biological Sciences Tarbiat Modares University Tehran Iran

6. Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences Shiraz Iran

7. Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies Shiraz University of Medical Sciences Shiraz Iran

8. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN) Munich Germany

Abstract

AbstractCreating cellular homeostasis within a defined tissue typically relates to the processes of apoptosis and efferocytosis. A great example here is cell debris that must be removed to prevent unwanted inflammatory responses and then reduce autoimmunity. In view of that, defective efferocytosis is often assumed to be responsible for the improper clearance of apoptotic cells (ACs). This predicament triggers off inflammation and even results in disease development. Any disruption of phagocytic receptors, molecules as bridging groups, or signaling routes can also inhibit macrophage efferocytosis and lead to the impaired clearance of the apoptotic body. In this line, macrophages as professional phagocytic cells take the lead in the efferocytosis process. As well, insufficiency in macrophage efferocytosis facilitates the spread of a wide variety of diseases, including neurodegenerative diseases, kidney problems, types of cancer, asthma, and the like. Establishing the functions of macrophages in this respect can be thus useful in the treatment of many diseases. Against this background, this review aimed to recapitulate the knowledge about the mechanisms related to macrophage polarization under physiological or pathological conditions, and shed light on its interaction with efferocytosis.

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,General Medicine,Biochemistry

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