Metabolic profile of glyburide in human liver microsomes using LC-DAD-Q-TRAP-MS/MS

Author:

Ravindran Selvan1,Basu Sudipta1,Gorti Santosh Kapil Kumar1,Surve Prashant1,Sloka Navya1

Affiliation:

1. Department of Biotransformation, Drug Metabolism and Pharmacokinetics Unit; Sai Life Sciences Limited; International Biotech Park, Phase-II, Hinjewadi; Pune-411 057; India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference10 articles.

1. Glyburide: a second-generation hypoglycemic agent. History, chemistry, metabolism, pharmacokinetics, clinical use and adverse effects;Feldman;Pharmacotheraphy,1985

2. Pharmacokinetics of glibenclamide and its metabolites in diabetic patients with impaired renal function;Jonsson;European Journal of Clinical Pharmacology,1998

3. Identification of glyburide metabolites formed by hepatic and placental microsomes of humans and baboons;Ravindran;Biochemical Pharmacology,2006

4. Determining quantity of metabolites without synthetic standards: an approach using LC-PDA-MS;Ravindran;International Journal of Chemical and Analytical Science,2011a

5. Optimal use of mass spec scan modes to identify an unknown metabolite;Ravindran;Drug Invention Today,2011b

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