An open‐label study to estimate the effect of steady‐state erythromycin on the pharmacokinetics, pharmacodynamics, and safety of a single dose of rivaroxaban in subjects with renal impairment and normal renal function

Author:

Moore Kenneth T.1,Vaidyanathan Seema1,Natarajan Jaya2,Ariyawansa Jay2,Haskell Lloyd2,Turner Kenneth C.1

Affiliation:

1. Janssen Research and DevelopmentLLCTitusvilleNJUSA

2. Janssen Research and DevelopmentLLCRaritanNJUSA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference24 articles.

1. The discovery and development of rivaroxaban, an oral, direct factor Xa inhibitor

2. Bayer Pharma AG. Xarelto® (rivaroxaban) Summary of Product Characteristics. 2013. Available at:http://www.xarelto.com/en/information‐on‐xarelto/summary‐of‐product‐characteristics/Accessed May 1 2014.

3. Effects of age, weight, gender and renal function in a pooled analysis of four phase III studies of rivaroxaban for prevention of venous thromboembolism after major orthopedic surgery;Bauer KA;Blood (ASH Annual Meeting Abstracts),2008

4. Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement

5. Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Hip Arthroplasty

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