Development and validation of a multiplex UHPLC-MS/MS assay with stable isotopic internal standards for the monitoring of the plasma concentrations of the antiretroviral drugs bictegravir, cabotegravir, doravirine, and rilpivirine in people living with HI

Author:

Courlet Perrine1ORCID,Alves Saldanha Susana1,Cavassini Matthias2,Marzolini Catia34,Choong Eva1,Csajka Chantal567,Günthard Huldrych F.89,André Pascal1,Buclin Thierry1,Desfontaine Vincent1,Decosterd Laurent Arthur1ORCID

Affiliation:

1. Service of Clinical Pharmacology; Lausanne University Hospital and University of Lausanne; Lausanne Switzerland

2. Service of Infectious Diseases; Lausanne University Hospital and University of Lausanne; Lausanne Switzerland

3. Division of Infectious Diseases and Hospital Epidemiology; University Hospital of Basel; Basel Switzerland

4. University of Basel; Basel Switzerland

5. Centre for Research and Innovation in Clinical Pharmaceutical Sciences; University Hospital and University of Lausanne; Lausanne Switzerland

6. Institute of Pharmaceutical Sciences of Western Switzerland; University of Geneva, University of Lausanne; Geneva Switzerland

7. School of Pharmaceutical Sciences; University of Geneva; Geneva Switzerland

8. Division of Infectious Diseases and Hospital Epidemiology; University Hospital Zurich; Switzerland

9. Institute of Medical Virology, Swiss National Reference Centre for Retroviruses; University of Zurich; Zurich Switzerland

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Wiley

Subject

Spectroscopy

Reference52 articles.

1. Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2018 recommendations of the International Antiviral Society-USA Panel;Saag;JAMA,2018

2. Adherence and Viral Suppression Among Participants of the Patient-centered Human Immunodeficiency Virus (HIV) Care Model Project: A Collaboration Between Community-based Pharmacists and HIV Clinical Providers;Byrd;Infect Dis Soc Am,2020

3. Self-reported nonadherence to antiretroviral therapy as a predictor of viral failure and mortality;Glass;AIDS,2015

4. Long-acting HIV drugs advanced to overcome adherence challenge;Dolgin;Nat Med,2014

5. Mills A. The future of long-acting injectable ART: how will patients respond? 2020 https://www.clinicaloptions.com/hiv/clinicalthought?q&sortBy&sortOrder=asc&page=1

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