Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease

Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease—A Pilot Study

Published:2020-02-12 Issue:6 Volume:60 Page:744-750
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharmacology

Author:

Sathe Abhishek G.¹,Tuite Paul²,Chen Chi³,Ma Yiwei³,Chen Wei⁴,Cloyd James¹,Low Walter C.⁵,Steer Clifford J.⁶,Lee Byeong‐Yeul⁴,Zhu Xiao‐Hong⁴,Coles Lisa D.¹

Affiliation:

1. Center for Orphan Drug Research and Department of Experimental and Clinical PharmacologyCollege of Pharmacy Minneapolis Minnesota USA

2. Department of NeurologyMedical SchoolUniversity of Minnesota Minneapolis Minnesota USA

3. Department of Food Science and NutritionCollege of FoodAgricultural and Natural Resource SciencesUniversity of Minnesota St. Paul Minnesota USA

4. Center for Magnetic Resonance ResearchDepartment of RadiologyMedical SchoolUniversity of Minnesota Minneapolis Minnesota USA

5. Department of NeurosurgeryMedical SchoolUniversity of Minnesota Minneapolis Minnesota USA

6. Departments of Medicine and GeneticsCell Biology and DevelopmentMedical SchoolUniversity of Minnesota Minneapolis Minnesota USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.1575

Reference34 articles.

1. Mitochondria in the aetiology and pathogenesis of Parkinson's disease

2. Oxidative stress and Parkinson's disease;Blesa J;Front Neuroanat.,2015

3. Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

4. Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

5. Mitochondrial Complex I Deficiency in Parkinson's Disease

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