Affiliation:
1. Stine Research Center FMC Agricultural Solutions Newark Delaware USA
Abstract
AbstractBACKGROUNDInsects of the order Lepidoptera are among the most destructive global pests, causing billions of dollars in damage annually. A new class of N‐arylpyrazole‐4‐methylpiperidines with potent activity on lepidopteran species has been discovered.RESULTSIn a high‐throughput insecticide screen compound 1 was identified to possess modest activity on the lepidopteran insect Plutella xylostella. Optimization of 1 to compound 42 resulted in a compound with excellent activity on Spodoptera exigua, Spodoptera frugiperda, and Helicoverpa zea with median lethal concentrations values of 2.8, 1.4, and 12.5 ppm respectively. Although the mode of action remains unknown, these compounds do not appear to work by many of the known biochemical mechanisms of insect control.CONCLUSIONN‐Arylpyrazole‐4‐methylpiperidines represent a new class of insecticides with excellent activity on a broad spectrum of lepidopteran pests. Studies to date indicate the potential for a novel mode of action; however, the target site is unknown at present. © 2023 Society of Chemical Industry.
Subject
Insect Science,Agronomy and Crop Science,General Medicine
Cited by
2 articles.
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