Development and validation of a generic RP‐HPLC PDA method for the simultaneous separation and quantification of active ingredients in cold and cough medicines

Author:

Dongala Thirupathi12ORCID,Katari Naresh Kumar23ORCID,Palakurthi Ashok Kumar1,Jonnalagadda Sreekantha B.3ORCID

Affiliation:

1. Aurex Laboratories LLC NJ USA

2. Department of ChemistryGITAM deemed to be University Hyderabad Telangana India

3. School of Chemistry & Physics, College of Agriculture, Engineering and Science, Westville CampusUniversity of KwaZulu‐Natal Durban South Africa

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference29 articles.

1. Simultaneous determination of ambroxol hydrochloride and guaifenesin by HPLC, TLC spectrodensitometric and multivariate calibration methods in pure form and in cough–cold formulations;Abdelkawy M.;Journal of Chromatography and Separation Techniques,2011

2. A new hydrophilic interaction liquid chromatographic (HILIC) procedure for the simultaneous determination of pseudoephedrine hydrochloride (PSH), diphenhydramine hydrochloride (DPH) and dextromethorphan hydrobromide (DXH) in cough–cold formulations;Ali M. S.;Journal of Pharmaceutical and Biomedical Analysis,2007

3. Spectrophotometric estimation of guaifenesin and salbutamol in pure and tablet dosage form by using different methods;Bankar A. A.;Der Pharma Chemica.,2013

4. A rapid HPLC assay for the determination of dextro‐propoxyphene related substance in combination with aspirin, acetaminophen, and caffeine in tablet and capsule formulations;Burge L. J.;Journal of Liquid Chromatography,2003

5. HPLC method development and validation:simultaneous determination of active ingredients in cough and cold pharmaceuticals;Çaglar H.;International Journal of Pharmacy and Pharmaceutical Sciences,2014

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