Synthesis, characterization, crystal structure, thermal and redox behaviour and antiproliferative studies of morpholine‐based two copper(II) compounds

Abstract

Two novel copper(II) complexes, [Cu(L)(Cl)2](H2O) (1) and [Cu(L)(N3)2] (2), have been synthesized from a morpholine‐based N,N,N donor tridentate Schiff base ligand, (E)‐N‐(2‐morpholinoethyl)‐1‐phenyl‐1‐(pyridin‐2‐yl)methanimine (L). Ligand (L) and its stabilized complexes, 1 and 2, have been comprehensively characterized by different physical and spectroscopic techniques. Solid‐state single‐crystal X‐ray structures of both 1 and 2 have been determined. Powder X‐ray diffraction studies on the bulk samples of 1 and 2 have been executed to demonstrate that the synthesized bulk materials retain their solid‐phase purity as that exists in the single crystals. Cyclic voltammetric experiments have been done to demonstrate the redox behaviour of 1 and 2. UV–vis spectra of the copper(II) complexes with variation in time were accrued to probe that both 1 and 2 retain their stability in solution. Thermogravimetric analysis (TGA) has been performed to collate the thermal stability of 1 along with its possible thermal degradation behaviour. Room temperature magnetic moments of 1 and 2 have been determined. Cytotoxic activity of 1 and 2 has been screened against non‐small human lung cancer cell, A549.