Improved performance of the SH test as an in vitro skin sensitization test with a new predictive model and decision tree

Author:

Imai Noriyasu12,Takeyoshi Midori1,Aizawa Sakiko1,Tsurumaki Mika1,Kurosawa Masaharu1,Toyoda Akemi3,Sugiyama Maki3,Kasahara Kaoru3,Ogata Shinichi2,Omori Takashi4,Hirota Morihiko5

Affiliation:

1. Safety and Analytical Research Laboratories KOSÉ Corporation Tokyo Japan

2. Graduate School of Environment and Information Sciences Yokohama National University Yokohama Japan

3. Frontier Research Laboratories POLA Chemical Industries, Inc. Yokohama Japan

4. Division of Biostatistics Department of Social/Community Medicine and Health Science Kobe University School of Medicine Kobe Japan

5. Brand Value R&D Institute Shiseido Co., Ltd. Yokohama Japan

Publisher

Wiley

Subject

Toxicology

Reference37 articles.

1. Development of an in vitro skin sensitization test using human cell lines: The human Cell Line Activation Test (h-CLAT)

2. Directive 2003/15/EC of the European Parliament and of the council of 27 February 2003 amending council directive 76/768/EEC on the approximation of the laws of the member states relating to cosmetic products;Council of the European Union and European Parliament;Official Journal of European Union,2003

3. EURL ECVAM recommendation on the KeratinoSens™ assay for skin sensitisation testing;European Reference Laboratory for Alternatives to Animal Testing;Publications Office of the European Union,2014

4. Development of a prediction method for skin sensitization using novel cysteine and lysine derivatives

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