Affiliation:
1. Department of Integrated Science and Technology Faculty of Science and Technology Oita University Dannoharu, 700 Oita city 870-1192 Japan
2. Institute for Research Management Oita University Dannoharu, 700 Oita city 870-1192 Japan
Abstract
AbstractIn this study, we attempted to improve the quantum yield of upconversion nanoparticles to achieve high efficiency of amyloid fibril decomposition cascade induced by near‐infrared‐active upconversion nanoparticles complexed with photosensitizers. The effects of the solvothermal reaction time on the crystalline phase of polyethylenimine‐coated NaYF4 : Yb3+/Er3+ were studied, while maintaining constant reaction temperature and concentration of the dopants Yb3+ and Er3+. We found that an increased reaction time resulted in the conversion of the crystalline phase from the cubic α‐ to hexagonal β‐forms with a higher upconversion quantum yield. In addition, the prolonged reaction time effectively increased the ratio of green (2H11/2 and 4S3/2→4I15/2) to red (4F9/2→4I15/2) emissions, increasing the 1O2 generation via photosensitization to approximately 10 times that of conventional ones. Consequently, the efficiency of the amyloid fibril decomposition cascade induced by upconversion nanoparticles complexed with photosensitizers was improved.
Funder
Ministry of Education, Culture, Sports, Science and Technology
Adaptable and Seamless Technology Transfer Program through Target-Driven R and D
Japan Science and Technology Agency
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Analytical Chemistry