Resolution of heterogeneous charged antibody aggregates via multimodal chromatography: A comparison to conventional approaches

Author:

Chmielowski Rebecca A.1,Meissner Sandra1,Roush David1,Linden Thomas O.1,Glowacki Edward1,Konietzko Janelle2,Nti-Gyabaah Joseph3

Affiliation:

1. Merck and Co., MSD, Biologics Process Development, Process Development and Engineering; Kenilworth NJ 07033

2. Merck and Co., MSD, Vaccine Process Development; West Point PA 19486

3. Amgen, Inc.; West Greenwich RI 02817

Publisher

Wiley

Subject

Biotechnology

Reference35 articles.

1. Aggregates in monoclonal antibody manufacturing processes;Vazquez-Rey;Biotechnol Bioeng,2011

2. Protein misfolding and aggregation research: some thoughts on improving quality and utility;Murphy;Biotechnol Prog,2013

3. Protein misfolding and aggregation;Murphy;Biotechnol Prog,2007

4. Quality attributes of recombinant therapeutic proteins: an assessment of impact on safety and efficacy as part of a quality by design development approach;Eon-Duval;Biotechnol Prog,2012

5. Aggregates in MAbs and recombinant therapeutic proteins: a regulatory perspective;Cordoba-Rodriguez;BioPharm Int,2008

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