Tumour-associated macrophage-mediated survival of myeloma cells through STAT3 activation

Author:

De Beule Nathan1,De Veirman Kim1,Maes Ken1,De Bruyne Elke1,Menu Eline1,Breckpot Karine2,De Raeve Hendrik3,Van Rampelbergh Rian3,Van Ginderachter Jo A45,Schots Rik6,Van Valckenborgh Els1,Vanderkerken Karin1

Affiliation:

1. Laboratory of Haematology and Immunology, Myeloma Centre Brussels; Vrije Universiteit Brussel; Brussels Belgium

2. Laboratory of Molecular and Cellular Technology; Vrije Universiteit Brussel; Brussels Belgium

3. Department of Pathology; Universitair Ziekenhuis Brussel; Brussels Belgium

4. Laboratory of Cellular and Molecular Immunology; Vrije Universiteit Brussel; Brussels Belgium

5. Myeloid Cell Immunology Laboratory, VIB Inflammation Research Centre; Ghent Belgium

6. Department of Clinical Haematology; Universitair Ziekenhuis Brussel; Brussels Belgium

Funder

SRP-VUB

Seventh Framework Programme

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference42 articles.

1. Multiple myeloma;Raab;Lancet,2009

2. National Cancer Institute http://seer.cancer.gov/statfacts/html/mulmy.html

3. Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR);Hazlehurst;Oncogene,2000

4. Multidrug resistance in cancer: role of Atp-dependent transporters;Hazlehurst;Cancer Res,2001

5. β1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation;Shain;Cancer Res,2009

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