Race‐related population attributable fraction of preventable risk factors of dementia: A Latino population‐based study

Author:

Borelli Wyllians Vendramini12,Formoso Carolina Rodrigues23,Bieger Andrei34,Ferreira Pamela Lukasewicz5,Zimmer Eduardo R.1,Pascoal Tharick Ali5,Chaves Marcia Lorena Fagundes23,Castilhos Raphael Machado23

Affiliation:

1. Pharmacology and Therapeutics Research Program Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil

2. Cognitive and Behavioral Neurology Center Neurology Service Hospital de Clínicas de Porto Alegre (HCPA) Porto Alegre Brazil

3. Faculty of Medicine Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil

4. Department of Biochemistry Institute of Health Sciences Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Brazil

5. Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA

Abstract

AbstractBackgroundRisk factors for dementia have distinct frequency and impact in relation to race. Our aim was to identify differences in modifiable risk factors of dementia related to races and estimate their population attributable fraction (PAF).MethodsAn epidemiological cohort was used to estimate the prevalence of 10 modifiable risk factors for dementia among five races—White, Black, Brown, Asian, and Indigenous. Sample weighting was used to estimate the prevalence and PAF of each risk factor in each race.ResultsA total of 9070 individuals were included. Overall adjusted PAF was the lowest in Indigenous (38.9%), and Asian individuals (41.2%). Race‐related prevalence of individual risk factors was widely variable in our population, but hearing loss was the most important contributor to the overall PAF in all races.ConclusionsPublic policies aiming to reduce preventable risk factors for dementia should take into consideration the race of the target populations.HIGHLIGHTS Preventable risk factors for dementia vary according to race. Hearing loss presented the highest prevalence among all races studied. Indigenous and Asian individuals presented the lowest population attributable fractions. Black and Brown individuals were more vulnerable to social determinants.

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

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