Development of a miniature bioreactor model to study the impact of <scp>pH</scp> and <scp>DOT</scp> fluctuations on <scp>CHO</scp> cell culture performance as a tool to understanding heterogeneity effects at large‐scale-Reference-Cited by-同舟云学术

Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity effects at large‐scale

Published:2022-05-07 Issue:4 Volume:38 Page:
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnology Progress

Author:

Zakrzewski Roman¹^ORCID,Lee Kenneth²,Lye Gary J.¹

Affiliation:

1. The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering University College London London UK

2. Biopharmaceutical Development: Bioprocess Technologies and Engineering AstraZeneca Gaithersburg USA

Funder

Engineering and Physical Sciences Research Council

Publisher

Wiley

Subject

Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.3264

Reference55 articles.

1. A review of advanced small-scale parallel bioreactor technology for accelerated process development: Current state and future need

2. A practical approach in bioreactor scale-up and process transfer using a combination of constantP/Vand vvm as the criterion

3. A systematic mass-transfer modeling approach for mammalian cell culture bioreactor scale-up

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