Affiliation:
1. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi China
2. University of Chinese Academy of Sciences Beijing China
3. College of Pharmacy Heze University Heze Shandong China
Abstract
AbstractThe fingerprint of Vernonia anthelmintica effective part (VAEP) from 15 different producing areas was established, followed by cluster analysis and principal component analysis. The relationship between the fingerprint and the melanogenesis‐promoting activity of VAEP was then analyzed using the grey correlation degree and the orthogonal partial least square method. The characteristic peaks reflecting the pharmacodynamic effect of VAEP were identified as vernodalin, 3,5‐O‐dicaffeoyl quinic acid (3,5‐diCQA), and butin. Based on the distribution characteristics of these components in plants from different habitats and the verification of results from the spectrum–effect relationship, vernodalin and 3,5‐diCQA can be used as characteristic components for quality control and pharmacodynamic assessment of V. anthelmintica products. This research establishes a theoretical foundation for planting areas and provides a scientific evaluation of the melanogenesis‐promoting effect of V. anthelmintica.