New homo‐bimetallic complexes of dihydrazone‐oxime ligand incorporating isatinic moiety: Preparation, characterization, theoretical, microbicidal, and anticancer investigation

Abstract

A new series of dihydrazone‐oxime ligand's homo‐bimetallic complexes of formulas [M2LCl5(H2O)3].nH2O (M=Fe3+, n=0; Ru3+, n=2), [M2L((O)CH3COO)3(H2O)5].nH2O (M=Co2+, Mn2+, Zn2+ or UO22+, n=4, 6, or 1) and [Cu2L(NO3)3(H2O)3] is designated from the reaction of 3‐((3‐(hydroxyimino)butan‐2‐ylidene)hydrazono)indolin‐2‐one (HL,1) with the salts of Fe3+, Ru3+, Co2+, Cu2+, Mn2+, Zn2+, and UO22+. The newly prepared compounds' structure was elucidated based on traditional techniques such as molar conductance, magnetic measurements, elemental, thermogravimetric (TGA) analyses, and mass spectrometry, as well as spectroscopic tools such as electronic absorption, infrared, nuclear magnetic resonance, mass, and electron spin resonance spectra. The values of complexes molar conductance in DMSO indicated that they were non‐electrolytes. The elemental analysis, in conjunction with other data obtained, confirmed that the ligand performed as a uni‐negative tetradentate chelator that bound two metal cations via the indoline carbonyl; deprotonated oximatic and azomethine groups adopt distorted octahedral or square pyramidal geometries. The chemical formula of these complexes was corroborated by TG analysis, which verified that the homo‐bimetallic complexes were degraded in three or four decaying steps in temperature range 50–596°C ended with the formation of metallic oxide. The prepared compounds' structural characterization was verified by DFT calculations utilizing DFT‐B3LYP technique with a basis set (6–311++G[d,p]). Theoretical calculations' results demonstrated that the homo‐bimetallic complexes' reactivity is higher than un‐complexed ligand's reactivity. The anticancer activity was determined versus three cell lines, namely, SKOV3, PC‐3, and HeLa cell lines. The assignment data revealed that the Zn2+ complex has a stronger inhibitory effect against the three cell lines. Additionally, the synthesized substances' in vitro microbicidal activity was performed versus a variety of bacterial and fungal species.